MOUNTAIN VIEW, Calif., Feb. 3, 2021 /PRNewswire/ — Turn Biotechnologies, a company developing medicines for currently untreatable age-related conditions, announced that it has acquired the global rights for new artificial niche (AN) technology that can be used to restore muscle stem cells damaged by aging.
The company licensed its AN technology from Stanford University, where it was developed by a researcher who serves as an advisor to Turn. AN technology is used to create a microenvironment that maintains stem cells in a quiescent state to repair or replace specific types of damaged tissue. The stem cell niche provides structural and trophic support and the appropriate homeostasis to regulate stem cell function.
Turn will use the niche technology in combination with its mRNA-based epigenetic reprogramming of age (ERA™) technology to restore specific cells’ youthful functionality, to trigger the body’s ability to fight age-related diseases.
“Our artificial niche technology expands the applicability of our ERA technology to a variety of diseases involving tissue that requires a microenvironment to maintain cell quiescence,” said Anja Krammer, Turn CEO. “By enveloping our ERA technology in the protective matrix of an artificial niche, we can reactivate muscle stem cells, as well as stem cells in tissues where quiescence is necessary to maintain stem cell functions.”
The combined use of Turn’s AN and ERA technologies may be able to restore function in hematopoietic, liver, brain, certain mesenchymal stem cells across different tissues and within the hair follicle.
This is Turn’s second licensing announcement since the start of the year. Earlier, the company revealed that it acquired the global rights for its ERA technology from Stanford University, where it was developed by three researchers who founded Turn. It is the first technology to maintain cellular identity while restoring specific cells’ youthful functionality, to trigger the body’s ability to fight age-related diseases.
As with ERA, the company announced that it has filed for patents to protect its AN technology in major-market nations on six continents.
“This is significant for our pipeline because the combination of AN with our ERA technology in murine models shows increased potency,” said Jay Sarkar, Turn’s chief technology officer and a company founder who helped to develop the ERA technology. “The studies show that aged muscle stem cells treated with this combination therapy fully regenerate age-related muscle dysfunctions.”
Turn’s technology uses messenger RNA to produce instructions that induce cells to treat or prevent disease. Use of mRNA, which led to the quick development of two COVID-19 vaccines, promises to revolutionize the development of therapeutics by making that development safer, faster, more efficient and extremely tunable to patient need.
Turn is currently completing pre-clinical research on tailored therapies targeting indications in dermatology, ophthalmology, osteo-arthritis and cartilage damage and musculature.
ABOUT TURN BIOTECHNOLOGIES
Turn is a pre-clinical-stage company focused on repairing tissue at the cellular level. Our proprietary mRNA technology combats the effects of aging in the epigenome, thus restoring optimal gene expression and enabling cells to function as vigorously as when they were younger. Our technology provides a platform from which to attack a variety of diseases related to age. The company has the financial backing of Methuselah Fund, which focuses its investments to extend the healthy human lifespan; Formic Ventures, which invests in biotech start-ups focused on human longevity; and Shanda Group, a private global investment firm. For more information, see www.turn.bio.
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